中文名 | TOLRESTAT |
英文名 | TOLRESTAT |
别名 | 托雷斯萘 托瑞司他 化合物 T17114 ALDOSE REDUCTASE抑制剂(TOLRESTAT) N-[[6-甲氧基-5-(三氟甲基)-1-萘基]硫代甲基]-N-甲基甘氨酸 |
英文别名 | Lorestat AY-27773 Alredase Aldredase TOLRESTAT N-[[6-Methoxy-5-(triiquoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglyeine N-[[6-Methoxy-5-(trifluoromethyl)naphthalen-1-yl]thioxomethyl]-N-methylglycine |
CAS | 82964-04-3 |
化学式 | C16H14F3NO3S |
分子量 | 357.35 |
密度 | 1.399±0.06 g/cm3(Predicted) |
熔点 | 164-165° |
沸点 | 498.1±55.0 °C(Predicted) |
溶解度 | 氯仿 (微溶) 、DMSO (微溶) 、乙酸乙酯 (微溶) |
酸度系数 | 3.49±0.10(Predicted) |
存储条件 | 2-8°C |
外观 | 粉末 |
颜色 | white to beige |
物化性质 | 结晶,熔点164-165℃。托瑞司他甲酯(Tolrestat Methyl Ester):C17H16F3NO3S。熔点109~110℃。 |
体内研究 | Tolrestat (1.8 mg/kg per day) causes a reversal to normal RBC sorbitol levels diabetic rats. In 21-day diabetic rats, the estimated ID in the sciatic nerve and lenses is 4.8 and about 20 for tolrestat, and 1.7 and 2.2 for (±)sorbinil,respectively. Either tolrestat or sorbinil inhibits tissue AR activity but does not significantly affect plasma lipoprotein levels, or affect the body weight of the mice or their general health. Accumulation of cholesterol-rich foam cells is significantly increased in aortic roots of tolrestat-fed mice. |
上游原料 | 甘氨酸甲酯盐酸盐 肌氨酸 1-萘甲酸 1,5-二甲基萘 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.798 ml | 13.992 ml | 27.984 ml |
5 mM | 0.56 ml | 2.798 ml | 5.597 ml |
10 mM | 0.28 ml | 1.399 ml | 2.798 ml |
5 mM | 0.056 ml | 0.28 ml | 0.56 ml |
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